In 2005, the Disease Transmission Advisory Group was started by the OPTN/UNOS to assess reports of potential risk for transmission of infection and malignancy from donor to recipient of solid organ transplant. Since that time, the group has become an established Advisory Committee of the OPTN/UNOS (the organization charged with oversight of transplantation in the United States). The committee is a multidisciplinary committee with diverse membership, including Infectious Diseases physicians, Surgeons, Nephrologists, Oncologists, Pathologists, Transplant Nursing, Laboratory Directors, Organ Procurement Organization representation, government representatives, and UNOS staff. Last year 157 cases were investigated, including 116 related to infections and 42 reports related to malignancy. These resulted in 37 documented proven or probable transmission events. Of the infections, although bacteria were most commonly reported, protozoa/parasites and fungi had the most proven transmissions, perhaps reflecting more efficient transfer of pathogens. Renal cell carcinomas were the most common malignancy reports; but there were more documented transmission events with pulmonary malignancies. This presentation will highlight the experiences of DTAC during its first 6 years and review the U.S. response to disease transmission events.