JUST RELEASED - TRANSPLANTATION DIRECT - JULY ISSUE

The July 2019 issue of Transplantation Direct offers basic science and clinical articles. The experimental articles look at the effects of PrC-210 as a free-radical scavenger to reduce kidney ischemia reperfusion injury in mice, and another article tests implantable oxygen sensors to monitor normothermic liver machine perfusion in rats. Clinically, regarding antibody-mediated kidney transplant rejection, there are reports on measuring peripheral CD19+ cell numbers in relation to rituximab treatment and on complement components as markers in the setting of DSA+ patients. Regarding acute rejection predictors, donor-specific cell-free DNA is tested as a diagnostic tool to predict acute rejection after liver transplantation. One group reports on whether kidneys from diabetic donors performed poorer, and this was assessed via pre and post-transplant biopsies. Another interesting paper examines the use of sodium bicarbonate to treat metabolic acidosis in kidney transplant recipients, especially with regard to rate of graft failure. From a surgical perspective in kidney transplantation, we have reports on the use of prophylactic wound drainage and on the management of bilateral utereral obstruction after pediatric en bloc transplantation. Please visit our Transplantation Direct website for full article details.

CLICK HERE TO ACCESS THIS Open Access ISSUE

LEARN HOW EASY IT IS TO APPLY FOR THE ISN-TTS SISTER TRANSPLANT CENTERS PROGRAM

In case you missed it

The informational webinar on how to apply for the ISN-TTS Sister Centers Program is posted. You can view the recorded session here! The presentation guides you through each step of the application process. In addition, they share some tips on how to prepare a successful application and answer questions from the audience. The deadline to apply is October 1st, 2019.

Speakers

Peter Kerr, Chair of the ISN Sister Centers Programs, and Philip J. O’Connell, Past-President of The Transplantation Society and Director of Transplantation, will guide you through each step of the application process.

They will share some handy tips on how to prepare a successful application and answer any questions you may have.

About the ISN-TTS Sister Transplant Centers Program

The ISN-TTS Sister Transplant Centers Program link renal and transplant centers in low-resource countries with established centers so they can benefit from educational support and work together to increase opportunities for kidney patients.

TTS EDUCATION COMMITTEE'S PRECISION MEDICINE WEBINAR SERIES LAUNCH!

The pre-recorded series, applies current perspectives on precision medicine and the role of translational research and scientists/physician’s engagement to the field of transplantation, illustrating how these approaches have led to significant advancements in the field. It provides further justification for deliberate, targeted efforts to cross-in translational transplant research. TTS will release 1 recording per month. TTS members are invited to submit comments and questions about each webinar for two weeks after the video is released on the site. The questions will be sent to the speaker and moderator to respond and we will post the responses. Click Here to view this month’s webinar. Dr. Maarten Naesens presents on System Biology and Precision Transplantation Medicine: The Complexity of the human and transplant model and the different layers of biological information; Current applications; Composite scores: clinical applications. This webinar is moderated by Valeria Mas.

*Note, you must be logged in to participate.

TRANSPLANTATION DIRECT - HIGHLIGHTED ARTICLE

Dr. Peri Husen, Editorial Fellow, Transplantation

DOES KIDNEY TRANSPLANTATION AFFECT SLEEP AND FATIGUE IN PATIENTS WITH KIDNEY DISEASE?

Tandukar S, Hou S, Yabes J, et al.
Transplantation Direct: June 2019 - Volume 5 - Issue 6 - p e461

Patients with cronic kidney disease (CKD) and end-stage kidney disease (ESKD) and renal replacement therapy (RRT) often suffer from sleep disorders and fatigue. In this article, Tandukar and coworkers assessed the role of kidney transplant (KTx) on improving sleep-disordered breething and fatigue in these patients. Patients with advanced CKD or ESKD were followed prospectively, and polysomnography as well as patient-reported symptom assessments were conducted. Sleep apnea (SA) severity was analyzed and compared between patients who did or did nor undergo KTx. The authors found that the majority of patients with renal disease suffers from SA, but that KTx did not change the severity of SA. However, patients with KTx reported improvements in fatigue and health-related quality of life. Overall, the clinical burden of sleep disorders and fatigue in patients with CKD and ESKD requires further attention and examination.

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