TITLE: EPITOPE MATCHING
FRIDAY, NOVEMBER 22, 2019 - 1:00 PM EST (MONTREAL TIME)

Objectives:

There are many new advances in the HLA world, and these technologies are developing at a rate faster than we know how to use them clinically. This session will examine the current evidence for and against epitope matching as well as review what is needed for future studies.

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TITLE: ETHICAL FRAMEWORK FOR VCA
FRIDAY, DECEMBER 6, 2019 2:00PM EST (MONTREAL TIME)

Objectives:

Articulate the ethical questions in VCA, Describe the differences in the ethical challenges between VCA and Solid Organ Transplants and enumerate possible solutions.

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Dr. Peri Husen, Editorial Fellow, Transplantation

Incidentally Detected Malignancies in Lung Transplant Explants

Amratia DA, Hunt WR, Neujahr D, et al.
Transplantation Direct: November 2019 - Volume 5 - Issue 11 - doi: 10.1097/TXD.0000000000000947

In this article, Amratia and coworkers assess the outcome of patients undergoing lung transplantation with incidental malignancies found upon explantation of their lungs. As active malignancy remains an absolute contraindication for lung transplantation, incidental findings of malignancy in explanted lungs at the time of transplantation have been described in the literature. The population of lung transplant recipients is at high risk for developing malignancy. However, radiologic findings may be missed due to parenchymal changes of lung architecture in this population. In this study, unexpected neoplasms were found in 9 / 407 (2.2%) of patients with initial lung transplantation. Most cases were found to have localized disease of mainly adenocarcinoma. Patients with localized primary NSCLS had a 3-year survival of 54.4%. These findings as well as the assessment of post-transplant outcome was analyzed and reflected by a thorough literature review of the authors. Overall, this article highlights a rather rare but interesting event with crucial clinical importance.

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The TTS-ILTS Paired Transplant Centers Program is a collaboration between The Transplantation Society (TTS) and the International Liver Transplantation Society (ILTS) supporting new liver transplant programs in emerging countries.

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Nov. 12 - Managing the risk for infection is one of the primary tasks in optimizing outcomes for solid organ transplant recipients. And while infection risk is highest during the first year after transplantation, ongoing vigilance is required for the remainder of the patient’s life.

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Nov. 18 - Early-onset pneumonia with multidrug-resistant organisms is a major concern for patients who have received a liver transplant, and pre- and intra-operative risk factors influence its development, according to study data.

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Nov. 13 - In a study recently published in Nature Biomedical Engineering, bioengineered livers created by decellularization and recellularization were implanted into pigs, where they were able to sustain continuous perfusion for up to 15 days.

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Nov. 14 - Older adults with blood cancers can benefit from a team-based, holistic evaluation before undergoing transplantation, according to a new study. The study found that patients treated with this approach experienced better transplantation outcomes and survival rates.

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